Medicine and Health

Nationwide Incidence and Clinical Outcomes of COVID-19 Vaccination-Related Myocarditis in Korea

J. Y. Cho, K. H. Kim, et al.

This nationwide study conducted by Jae Yeong Cho and colleagues reveals that while COVID-19 vaccination-related myocarditis is rare, it poses significant risks, especially among young men receiving mRNA vaccines. With 480 confirmed cases, including severe instances and eight sudden cardiac deaths, this research underscores the necessity for vigilant monitoring of vaccine-related heart conditions.

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Abstract

This nationwide study analyzed the incidence and clinical courses of COVID-19 vaccination-related myocarditis (VRM) in Korea. Among 44,276,704 vaccinated individuals, 480 VRM cases were confirmed (1.08 cases per 100,000 persons). VRM incidence was higher in men and with mRNA vaccines. Severe VRM (19.8% of total VRM cases) included ICU admissions, fulminant myocarditis, ECMO, and deaths. Eight sudden cardiac deaths (SCDs) were autopsy-confirmed as attributable to VRM, all in individuals under 45 years receiving mRNA vaccines. While VRM was rare, severe cases and SCD warrant close monitoring.

Publisher

European Heart Journal

Published On

Jun 02, 2023

Authors

Jae Yeong Cho, Kye Hun Kim, Nuri Lee, Soo Hyeon Cho, Seung Yun Kim, Eun Kyoung Kim, Jae-Hyeong Park, Eui-Young Choi, Jin-Oh Choi, Hyukjin Park, Hyung Yoon Kim, Hyun Ju Yoon, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, COVID-19 Vaccination Task Force Adverse Event Investigation Team

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