This randomized controlled trial investigated the effects of a fasting-mimicking diet (FMD) and glycocalyx mimetic supplementation (Endocalyx™) on microvascular function in Surinamese South-Asian patients with type 2 diabetes (SA-T2DM). While FMD showed temporary improvements in BMI and HbA1c, it worsened microvascular health. In contrast, Endocalyx™ reduced urinary MCP-1 and improved microvascular health, an effect sustained at follow-up. These findings suggest that glycocalyx mimetics, but not FMD, may be beneficial for preserving microvascular health in this high-risk population.
Publisher
Nutrition & Diabetes
Published On
Apr 10, 2024
Authors
Anouk I. M. van der Velden, Daphne H. T. IJpelaar, Prataap K. Chandie Shaw, Hanno Pijl, Hans Vink, Johan van der Vlag, Ton J. Rabelink, Bernard M. van den Berg
Tags
fasting-mimicking diet
glycocalyx mimetics
microvascular function
type 2 diabetes
Surinamese South-Asian patients
health preservation
urinary MCP-1
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