Medicine and Health

Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands: A randomized controlled trial

A. I. M. V. D. Velden, D. H. T. Ijpelaar, et al.

This groundbreaking randomized controlled trial conducted by Anouk I. M. van der Velden and colleagues reveals the unexpected effects of a fasting-mimicking diet and glycocalyx mimetic supplementation on microvascular health in Surinamese South-Asian patients with type 2 diabetes. While the fasting-mimicking diet had temporary benefits, it surprisingly worsened microvascular health. In contrast, glycocalyx mimetics showed promise in preserving microvascular function. Explore these essential findings that could change approaches to diabetes management!

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Abstract

This randomized controlled trial investigated the effects of a fasting-mimicking diet (FMD) and glycocalyx mimetic supplementation (Endocalyx™) on microvascular function in Surinamese South-Asian patients with type 2 diabetes (SA-T2DM). While FMD showed temporary improvements in BMI and HbA1c, it worsened microvascular health. In contrast, Endocalyx™ reduced urinary MCP-1 and improved microvascular health, an effect sustained at follow-up. These findings suggest that glycocalyx mimetics, but not FMD, may be beneficial for preserving microvascular health in this high-risk population.

Publisher

Nutrition & Diabetes

Published On

Apr 10, 2024

Authors

Anouk I. M. van der Velden, Daphne H. T. IJpelaar, Prataap K. Chandie Shaw, Hanno Pijl, Hans Vink, Johan van der Vlag, Ton J. Rabelink, Bernard M. van den Berg

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