Medicine and Health

RNA profiles reveal signatures of future health and disease in pregnancy

M. Rasmussen, M. Reddy, et al.

Exciting findings reveal that plasma cell-free RNA (cfRNA) can predict pre-eclampsia months before it occurs, showcasing an innovative approach to tackling rising maternal morbidity and mortality. This pivotal research was conducted by Morten Rasmussen, Mitsu Reddy, Rory Nolan, Joan Camunas-Soler, Arkady Khodursky, and their team.

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Abstract

Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden. This study demonstrates the ability of plasma cell-free RNA (cfRNA) to reveal patterns of normal pregnancy progression and determine the risk of developing pre-eclampsia months before clinical presentation. Using comprehensive transcriptome data from eight independent cohorts (1,840 pregnancies) and retrospective analyses of 2,523 pregnancies, cfRNA signatures predicted pre-eclampsia with 82.3% sensitivity and specificity, exceeding conventional methods.

Publisher

Nature

Published On

Jan 20, 2022

Authors

Morten Rasmussen, Mitsu Reddy, Rory Nolan, Joan Camunas-Soler, Arkady Khodursky, Nikolai M. Scheller, David E. Cantonwine, Line Engelbrecht Sørensen, Jia Dai, Arup Dutta, Tiffany Brundage, Faroq Siddiqui, Mainou Thao, Elaine P. S. Gee, Johnny Lai, Courtney Baruch-Gravet, Mark K. Santillán, Sadaf Debs, Shauli M. Amé, Said M. Ali, Melanie Adkins, Mark A. DePistro, Manfred Lee, Eugeni Namsarev, Dorte Jensen (Gybel-Brak), Lillian Skibsted, James A. Licht, Donna A. Santillán, Sunil Sazawal, Rachel M. Tribble, James M. Roberts, Aneesh Jain, Esther Hogdall, Claudia Holzman, Stephen R. Quake, Micheal A. Elovitz, Thomas F. McElrath

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