Biology

Reconstructing aspects of human embryogenesis with pluripotent stem cells

B. Sozen, V. Jorgensen, et al.

This groundbreaking study, led by Berna Sozen and colleagues, explores early human embryo development using expanded pluripotent stem cells. By creating self-organizing cystic structures that resemble natural embryonic development, the research uncovers the intricacies of blastocyst-like morphology and cell lineage, providing valuable insights into human embryogenesis and its divergence from natural processes.

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Abstract

Understanding human development is crucial. This study models early human embryo development using expanded pluripotent stem cells (EPSCs) in 3D. A protocol generated self-organizing cystic structures mimicking pre-implantation development, forming blastocyst-like morphology and transitioning to post-implantation-like organization. Single-cell RNA sequencing revealed cell subsets resembling epiblast, hypoblast, and trophectoderm lineages, though with key differences from natural blastocysts. This stem cell platform provides insights into human embryogenesis but also highlights divergences from natural development.

Publisher

NATURE COMMUNICATIONS

Published On

Sep 21, 2021

Authors

Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz

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