Medicine and Health

Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes

H. Kang, B. Min, et al.

This groundbreaking research reveals the critical role of pyruvate dehydrogenase kinases (PDK1/2) in diet-induced obesity. Mice deficient in PDK2 exhibited remarkable resistance to obesity, showcasing reduced fat accumulation and enhanced insulin sensitivity. The study, conducted by notable researchers including Hyeon-Ji Kang and Byong-Keol Min, uncovers novel regulatory mechanisms of adipogenesis linked to HIF1α and lactate production, offering fresh insights into obesity management.