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Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase

Medicine and Health

Geraniol reverses obesity by improving conversion of WAT to BAT in high fat diet induced obese rats by inhibiting HMGCoA reductase

S. Chand, A. S. Tripathi, et al.

Discover how geraniol can combat HFD-induced obesity in rats! This research by Shushmita Chand and colleagues reveals that geraniol not only curtails body weight but also enhances metabolic profiles by converting white adipose tissue to brown. Dive into the findings that highlight the potential of geraniol in obesity management.

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Playback language: English
Abstract
This study investigated the protective effects of geraniol on high-fat-diet (HFD)-induced obesity in rats and explored its molecular mechanism. Obese rats were treated with geraniol (200 and 400 mg/kg p.o.) for four weeks. Geraniol treatment significantly reduced body weight, improved serum glucose and lipid profiles, and decreased the weight of adipose tissue and organs. In silico docking studies revealed that geraniol interacts with HMG-CoA reductase. The results suggest that geraniol reduces obesity by promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) through HMG-CoA reductase inhibition.
Publisher
Nutrition and Diabetes
Published On
Dec 05, 2023
Authors
Shushmita Chand, Alok Shiomurti Tripathi, Tabinda Hasan, Kavitha Ganesh, Mary Anne W. Cordero, Mohammad Yasir, Magdi E. A. Zaki, Pankaj Tripathi, Lucy Mohapatra, Rahul Kumar Maurya
Tags
geraniol
high-fat diet
obesity
HMG-CoA reductase
brown adipose tissue
metabolic profiles
rats

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