logo
ResearchBunny Logo
Abstract
This study investigated the protective effects of geraniol on high-fat-diet (HFD)-induced obesity in rats and explored its molecular mechanism. Obese rats were treated with geraniol (200 and 400 mg/kg p.o.) for four weeks. Geraniol treatment significantly reduced body weight, improved serum glucose and lipid profiles, and decreased the weight of adipose tissue and organs. In silico docking studies revealed that geraniol interacts with HMG-CoA reductase. The results suggest that geraniol reduces obesity by promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) through HMG-CoA reductase inhibition.
Publisher
Nutrition and Diabetes
Published On
Dec 05, 2023
Authors
Shushmita Chand, Alok Shiomurti Tripathi, Tabinda Hasan, Kavitha Ganesh, Mary Anne W. Cordero, Mohammad Yasir, Magdi E. A. Zaki, Pankaj Tripathi, Lucy Mohapatra, Rahul Kumar Maurya
Tags
geraniol
high-fat diet
obesity
HMG-CoA reductase
brown adipose tissue
metabolic profiles
rats

Related Publications

Explore these studies to deepen your understanding of the subject.

Short-term *Cudrania tricuspidata* fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters
Food Science and Technology

Short-term *Cudrania tricuspidata* fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters

J. Choi, M. Kim, et al.

Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal
Medicine and Health

Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal

Y. Zheng, A. Martin-morales, et al.

Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty
Medicine and Health

Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty

R. Ullah, C. Xue, et al.

Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes
Medicine and Health

Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes

H. Kang, B. Min, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny