Medicine and Health

Psychiatric polygenic risk as a predictor of COVID-19 risk and severity: insight into the genetic overlap between schizophrenia and COVID-19

M. Alemany-navarro, S. D. Almeida, et al.

Explore groundbreaking research by M. Alemany-Navarro and colleagues, revealing how polygenic risk scores for schizophrenia could predict COVID-19 susceptibility and severity, particularly among women. This study sheds light on the genetic ties between mental health and infectious diseases, paving the way for future discoveries!

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Playback language: English

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Abstract

This study investigates the predictive ability of polygenic risk scores (PRSs) derived from schizophrenia (SCZ), bipolar disorder (BD), and depression (DEP) risk alleles for COVID-19 susceptibility and severity. Using a sample of 11,977 COVID-19 cases and 5943 controls, the researchers found that the SCZ PRS significantly predicted COVID-19 risk, symptom presence, and hospitalization, particularly in women. No significant associations were found for BD or DEP PRSs. While the study suggests a potential genetic overlap between SCZ and COVID-19, especially in women, the predictive accuracy remained modest. Further research incorporating sex loci and rare variations is recommended.

Publisher

Translational Psychiatry

Published On

Jun 06, 2023

Authors

M. Alemany-Navarro, S. Diz-de Almeida, R. Cruz, J. A. Riancho, A. Rojas-Martínez, P. Lapunzina, C. Flores, A. Carracedo

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