Psychology

Educational attainment reduces the risk of suicide attempt among individuals with and without psychiatric disorders independent of cognition: a bidirectional and multivariable Mendelian randomization study with more than 815,000 participants

D. B. Rosoff, Z. A. Kaminsky, et al.

This exciting Mendelian randomization study, conducted by Daniel B Rosoff, Zachary A Kaminsky, Andrew M McIntosh, George Davey Smith, and Falk W Lohhoff, uncovers a fascinating causal relationship between educational attainment and a reduced risk of suicide attempts. Delving into the genetics of over 815,000 individuals, the research highlights the significant impact of educational factors, offering a new perspective on mental health prevention strategies.

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Abstract

This Mendelian randomization study investigated the causal relationship between educational attainment (EA), cognitive performance (CP), and suicide attempt risk using summary statistics from genome-wide association studies (GWAS) of over 815,000 white participants of European ancestry. Single-variable MR showed that both EA and CP appeared to reduce suicide attempt risk. However, multivariable MR analysis revealed that EA, but not CP, was the predominant independent risk factor for suicide attempts, even after accounting for psychiatric disorders and behavioral mediators. The findings suggest a causal link between higher EA and a reduced risk of suicide attempts.

Publisher

Translational Psychiatry

Published On

Authors

Daniel B Rosoff, Zachary A Kaminsky, Andrew M McIntosh, George Davey Smith, Falk W Lohhoff

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