Medicine and Health

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

J. Zhou, M. Li, et al.

This groundbreaking research by Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu, and Qian Chen unveils an innovative approach to combat intestinal inflammation in inflammatory bowel disease using engineered *Escherichia coli* Nissle 1917. The study shows that the enhanced probiotic, combined with chitosan and sodium alginate, significantly reduces inflammation and promotes gut health.

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Playback language: English

Index

Abstract

Reactive oxygen species (ROS) contribute to intestinal inflammation in inflammatory bowel disease (IBD). This study engineered *Escherichia coli* Nissle 1917 (ECN) to overexpress catalase and superoxide dismutase (ECN-PE) for ROS elimination. To enhance bioavailability, ECN-PE was coated with chitosan and sodium alginate. In a mouse IBD model, coated ECN-PE (ECN-PE(C/A)₂) effectively reduced inflammation, repaired epithelial barriers, and modulated gut microbiota, increasing beneficial bacteria like *Lachnospiraceae_NK4A136* and *Odoribacter*. This research supports the use of engineered probiotics for IBD treatment.

Publisher

NATURE COMMUNICATIONS

Published On

Jun 14, 2022

Authors

Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu, Qian Chen

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