Reactive oxygen species (ROS) contribute to intestinal inflammation in inflammatory bowel disease (IBD). This study engineered *Escherichia coli* Nissle 1917 (ECN) to overexpress catalase and superoxide dismutase (ECN-PE) for ROS elimination. To enhance bioavailability, ECN-PE was coated with chitosan and sodium alginate. In a mouse IBD model, coated ECN-PE (ECN-PE(C/A)₂) effectively reduced inflammation, repaired epithelial barriers, and modulated gut microbiota, increasing beneficial bacteria like *Lachnospiraceae_NK4A136* and *Odoribacter*. This research supports the use of engineered probiotics for IBD treatment.
Publisher
NATURE COMMUNICATIONS
Published On
Jun 14, 2022
Authors
Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu, Qian Chen
Tags
reactive oxygen species
inflammatory bowel disease
engineered probiotics
gut microbiota
intestinal inflammation
catalase
superoxide dismutase
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