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Galactooligosaccharides and *Limosilactobacillus reuteri* synergistically alleviate gut inflammation and barrier dysfunction by enriching *Bacteroides acidifaciens* for pentadecanoic acid biosynthesis

Medicine and Health

Galactooligosaccharides and *Limosilactobacillus reuteri* synergistically alleviate gut inflammation and barrier dysfunction by enriching *Bacteroides acidifaciens* for pentadecanoic acid biosynthesis

Y. Wu, X. Zhang, et al.

This groundbreaking study reveals the remarkable therapeutic effects of a synbiotic formulation of galactooligosaccharides and *Limosilactobacillus reuteri* in combating colitis. Researchers discovered that this synbiotic not only enhances gut health by boosting levels of *Bacteroides acidifaciens*, but also supports inflammation reduction through pentadecanoic acid synthesis. Conducted by Yujun Wu and colleagues, this research opens new avenues for treating inflammatory bowel disorders.

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Playback language: English
Abstract
This study investigates the therapeutic potential of a synbiotic composed of galactooligosaccharides (GOS) and *Limosilactobacillus reuteri* in a murine model of colitis. The synbiotic synergistically protects against intestinal inflammation and barrier dysfunction by enriching *Bacteroides acidifaciens*, which promotes pentadecanoic acid (C15:0) synthesis. The synbiotic, *B. acidifaciens*, and C15:0 each suppress inflammation and enhance tight junctions by inhibiting NF-κB activation. Reduced *B. acidifaciens* and C15:0 levels are observed in human UC patients and LPS-induced intestinal inflammation in pigs. These findings highlight the therapeutic potential of the synbiotic, *B. acidifaciens*, and C15:0 for UC and other intestinal inflammatory disorders.
Publisher
Nature Communications
Published On
Oct 28, 2024
Authors
Yujun Wu, Xiangyu Zhang, Xiaoyi Liu, Zhenguo Zhao, Shiyu Tao, Qian Xu, Jinbiao Zhao, Zhaolai Dai, Guolong Zhang, Dandan Han, Junjun Wang
Tags
synbiotic
colitis
intestinal inflammation
Bacteroides acidifaciens
pentadecanoic acid
therapeutic potential
inflammatory bowel disease

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