High sodium intake is linked to non-alcoholic fatty liver disease (NAFLD), but the mechanism is unclear. This study explores the role of chronic inflammation and the effect of β-carotene in this association using mediation analyses with C-reactive protein (CRP) and red cell distribution width (RDW) as mediators. Higher sodium intake increased NAFLD odds by upregulating inflammation, while β-carotene attenuated this association by downregulating inflammation.
Publisher
Nutrition and Diabetes
Published On
Sep 15, 2022
Authors
Yang Chen, Min Wu, Fuli Chen, Xiaoxiao Wen, Liancheng Zhao, Gang Li, Long Zhou
Tags
sodium intake
non-alcoholic fatty liver disease
inflammation
β-carotene
mediation analysis
C-reactive protein
red cell distribution width
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