Medicine and Health

A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease

R. Cheng, L. Wang, et al.

This groundbreaking study reveals the intricate relationship between exercise, diet, and gut microbiota in patients with nonalcoholic fatty liver disease (NAFLD) and prediabetes. Conducted by an esteemed team including Runtan Cheng and Lu Wang, the research offers insights into personalized intervention strategies that leverage host-gut microbiome interactions. Don’t miss the chance to explore how such interventions can mitigate liver fat and transform health outcomes.

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Abstract

Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. This study, an 8.6-month, four-arm randomized controlled trial (Aerobic exercise, Diet, Aerobic exercise + Diet, No intervention), analyzed gut microbiota composition in participants who completed the trial. Combined aerobic exercise and diet intervention were associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increased network connectivity and robustness between taxa. Personalized gut microbial networks at baseline could predict individual responses in liver fat to exercise intervention. Findings suggest avenues for developing personalized NAFLD intervention strategies based on host-gut microbiome interactions, but larger studies are needed.

Publisher

Nature Communications

Published On

May 10, 2022

Authors

Runtan Cheng, Lu Wang, Shenglong Le, Yifan Yang, Can Zhao, Xiangqi Zhang, Xin Yang, Ting Xu, Leiting Xu, Petri Wiklund, Jun Ge, Dajiang Lu, Chenhong Zhang, Luonan Chen, Sulin Cheng

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