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Potential role of inflammation in relation to dietary sodium and β-carotene with non-alcoholic fatty liver disease: a mediation analysis

Medicine and Health

Potential role of inflammation in relation to dietary sodium and β-carotene with non-alcoholic fatty liver disease: a mediation analysis

Y. Chen, M. Wu, et al.

This research by Yang Chen, Min Wu, Fuli Chen, Xiaoxiao Wen, Liancheng Zhao, Gang Li, and Long Zhou reveals that higher sodium intake is linked to increased odds of non-alcoholic fatty liver disease (NAFLD) through chronic inflammation. Interestingly, β-carotene appears to mitigate these effects by downregulating inflammation, providing a potential pathway for intervention.

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Playback language: English
Abstract
High sodium intake is linked to non-alcoholic fatty liver disease (NAFLD), but the mechanism is unclear. This study explores the role of chronic inflammation and the effect of β-carotene in this association using mediation analyses with C-reactive protein (CRP) and red cell distribution width (RDW) as mediators. Higher sodium intake increased NAFLD odds by upregulating inflammation, while β-carotene attenuated this association by downregulating inflammation.
Publisher
Nutrition and Diabetes
Published On
Sep 15, 2022
Authors
Yang Chen, Min Wu, Fuli Chen, Xiaoxiao Wen, Liancheng Zhao, Gang Li, Long Zhou
Tags
sodium intake
non-alcoholic fatty liver disease
inflammation
β-carotene
mediation analysis
C-reactive protein
red cell distribution width

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