Photobiocatalytic synthesis of chiral secondary fatty alcohols | ResearchBunny

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Abstract

This paper reports on photoenzymatic cascade reactions to transform unsaturated fatty acids into enantiomerically pure secondary fatty alcohols. The process involves a two-step approach: stereoselective hydration of the C=C double bond using oleate hydratases, followed by decarboxylation of the intermediate hydroxy acids using a photoactivated decarboxylase. A wide range of unsaturated fatty acids were successfully converted into enantiomerically pure fatty alcohols using this one-pot method.

Publisher

Nature Communications

Published On

May 07, 2020

Authors

Wuyuan Zhang, Jeong-Hoo Lee, Sabry H. H. Younes, Fabio Tonin, Peter-Leon Hagedoorn, Harald Pichler, Yoonjin Baeg, Jin-Byung Park, Robert Kourist, Frank Hollmann

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