Chemistry

Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids

C. Ye, D. R. Dansby, et al.

Discover a groundbreaking approach to synthesizing high-value α-amino acids in a single step! This research, conducted by Chen-Xi Ye, Drew R. Dansby, Shuming Chen, and Eric Meggers, harnesses iron catalysis and abundant carboxylic acids to provide an efficient and eco-friendly solution in the field of organic chemistry.

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Abstract

This paper reports a highly stereocontrolled, iron-catalyzed direct α-amination of carboxylic acid feedstock molecules, providing a single-step synthesis of high-value *N*-Boc-protected α-monosubstituted and α,α-disubstituted α-amino acids. The method uses abundant carboxylic acids, sustainable and earth-abundant iron catalysis, and the commonly used Boc protecting group, making it highly efficient and environmentally friendly.

Publisher

Nature Synthesis

Published On

Jul 01, 2023

Authors

Chen-Xi Ye, Drew R. Dansby, Shuming Chen, Eric Meggers

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