logo
ResearchBunny Logo
Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids

Biology

Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids

W. Zhang, J. Lee, et al.

Discover how researchers, including Wuyuan Zhang and Sabry H. H. Younes, have developed innovative photoenzymatic cascade reactions to convert unsaturated fatty acids into pure secondary fatty alcohols. This one-pot method harnesses the power of oleate hydratases and photoactivated decarboxylases, unlocking new pathways in chemical transformations.

00:00
00:00
Playback language: English
Abstract
This paper reports on photoenzymatic cascade reactions to transform unsaturated fatty acids into enantiomerically pure secondary fatty alcohols. The process involves a two-step approach: stereoselective hydration of the C=C double bond using oleate hydratases, followed by decarboxylation of the intermediate hydroxy acids using a photoactivated decarboxylase. A wide range of unsaturated fatty acids were successfully converted into enantiomerically pure fatty alcohols using this one-pot method.
Publisher
Nature Communications
Published On
May 07, 2020
Authors
Wuyuan Zhang, Jeong-Hoo Lee, Sabry H. H. Younes, Fabio Tonin, Peter-Leon Hagedoorn, Harald Pichler, Yoonjin Baeg, Jin-Byung Park, Robert Kourist, Frank Hollmann
Tags
photoenzymatic reactions
fatty acids
secondary fatty alcohols
stereoselective hydration
decarboxylation
biotechnology
one-pot method

Related Publications

Explore these studies to deepen your understanding of the subject.

Iridium-catalyzed enantioselective synthesis of chiral γ-amino alcohols and intermediates of (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine
Chemistry

Iridium-catalyzed enantioselective synthesis of chiral γ-amino alcohols and intermediates of (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine

C. Liu, L. Zhang, et al.

Electrocatalytic synthesis of heterocycles from biomass-derived furfuryl alcohols
Chemistry

Electrocatalytic synthesis of heterocycles from biomass-derived furfuryl alcohols

X. Liu, B. Li, et al.

Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids
Chemistry

Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids

C. Ye, D. R. Dansby, et al.

Large contribution of in-cloud production of secondary organic aerosol from biomass burning emissions
Environmental Studies and Forestry

Large contribution of in-cloud production of secondary organic aerosol from biomass burning emissions

T. Wang, K. Li, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny