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Neohesperidin Ameliorates Hepatic Steatosis and Insulin Resistance in High-Fat Diet-Fed Mice by Promoting PGC-1α-Mediated Mitochondrial Biogenesis

Medicine and Health

Neohesperidin Ameliorates Hepatic Steatosis and Insulin Resistance in High-Fat Diet-Fed Mice by Promoting PGC-1α-Mediated Mitochondrial Biogenesis

W. S.w., B. Y.f., et al.

Discover how neohesperidin (NHP), a flavonoid from Quzhou Fructus Aurantii, combats hepatic steatosis and insulin resistance in high-fat diet-fed mice. This promising research by Wang S.W., Bai Y.F., Zhang Y., and Li Y. reveals NHP's potential to enhance liver function and promote fatty acid oxidation.

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Playback language: English
Abstract
This study investigated the effects of neohesperidin (NHP), a flavonoid rich in Quzhou Fructus Aurantii, on hepatic steatosis and insulin resistance in high-fat diet (HFD)-fed mice. Results showed that NHP improved liver function, inhibited hepatic lipid accumulation, relieved hepatic inflammation and oxidative stress, suppressed fatty acid synthesis, and promoted fatty acid oxidation. Mechanistically, NHP increased hepatic mitochondrial biogenesis and PGC-1α expression via AMPK activation.
Publisher
Nutrition and Diabetes
Published On
Aug 05, 2020
Authors
Wang S.W., Bai Y.F., Zhang Y., Li Y.
Tags
neohesperidin
hepatic steatosis
insulin resistance
high-fat diet
lipid accumulation
mitochondrial biogenesis
AMPK activation

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