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Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

Food Science and Technology

Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

W. Song, Q. Sheng, et al.

This fascinating study conducted by Wei Song and colleagues reveals the critical link between high-fat diet-induced obesity and bone loss in mice, while highlighting the protective role of a healthy gut microbiome that supports bone health through short-chain fatty acid production. A remarkable fecal microbiota transplantation reversed bone loss, showcasing the gut's power in maintaining skeletal integrity.

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