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Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty

Medicine and Health

Alternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty

R. Ullah, C. Xue, et al.

This groundbreaking study by Rahim Ullah and colleagues explores alternate-day fasting's surprising effects on puberty and obesity in female mice. The results highlight ADF's potential to delay puberty in normal-weight mice while preventing obesity and early onset puberty in those on a high-fat diet. This research could open doors to innovative strategies for managing childhood obesity and precocious puberty.

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Playback language: English
Abstract
This study investigated the effects of alternate-day fasting (ADF) on pubertal development in normal-weight and high-fat diet (HFD)-induced obese female mice. ADF in normal-weight mice delayed puberty and reduced growth, while in HFD-fed mice, ADF prevented obesity and precocious puberty. The findings suggest a potential role for ADF in managing childhood obesity and precocious puberty, but further research is needed before clinical application.
Publisher
Nutrition and Diabetes
Published On
Oct 04, 2024
Authors
Rahim Ullah, Chuqing Xue, Senjie Wang, Zhewen Qin, Naveed Rauf, Shumin Zhan, Naimat Ullah Khan, Yi Shen, Yu-Dong Zhou, Junfen Fu
Tags
alternate-day fasting
puberty
obesity
female mice
high-fat diet
childhood obesity

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