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Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

Food Science and Technology

Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

W. Song, Q. Sheng, et al.

This fascinating study conducted by Wei Song and colleagues reveals the critical link between high-fat diet-induced obesity and bone loss in mice, while highlighting the protective role of a healthy gut microbiome that supports bone health through short-chain fatty acid production. A remarkable fecal microbiota transplantation reversed bone loss, showcasing the gut's power in maintaining skeletal integrity.

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Playback language: English
Abstract
This study investigated the effects of high-fat diet (HFD) and obesity on bone loss in mice. Researchers found that HFD-induced obesity, but not HFD alone, led to bone loss. Non-obese mice fed an HFD maintained healthy bones due to a gut microbiome that promoted short-chain fatty acid (SCFA) production. These SCFAs activated free fatty acid receptor 2 (FFAR2) and inhibited histone deacetylases, leading to increased Treg cell proliferation and inhibition of osteoclastogenesis. Fecal microbiota transplantation from non-obese mice to obese mice reversed bone loss, highlighting the importance of the gut microbiome in bone health.
Publisher
npj Science of Food
Published On
Apr 13, 2023
Authors
Wei Song, Qinglin Sheng, Yuying Bai, Li Li, Xin Ning, Yangeng Liu, Chen Song, Tianyi Wang, Xiaohua Dong, Yane Luo, Jinhong Hu, Lina Zhu, Xiaole Cui, Bing Chen, Lingling Li, Congli Cai, Haobo Cui, Tianli Yue
Tags
high-fat diet
obesity
bone loss
gut microbiome
short-chain fatty acids
fecal microbiota transplantation
osteoclastogenesis

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