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Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry

Chemistry

Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry

C. Zhu, H. Yue, et al.

Discover a groundbreaking three-component, reductive cascade reaction for arylalkylation of alkynes, developed by Chen Zhu, Huifeng Yue, and Magnus Rueping. This innovative approach yields a variety of trisubstituted alkenes with unparalleled chemo- and stereoselectivity, showcasing exclusive formation of *E* and *Z* isomers through distinct electrochemical and photocatalytic methods.

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Abstract
This paper reports a three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes, yielding a wide range of trisubstituted alkenes with excellent chemo- and stereoselectivity. Electrochemistry with nickel produces the *E* isomer exclusively, while photocatalysis with nickel yields the *Z* isomer. A photo-assisted electrochemically enabled nickel-catalyzed protocol selectively delivers *Z*-trisubstituted alkenes without added photocatalysts.
Publisher
Nature Communications
Published On
Jun 10, 2022
Authors
Chen Zhu, Huifeng Yue, Magnus Rueping
Tags
reductive cascade
cross-coupling reaction
arylalkylation
trisubstituted alkenes
electrochemistry
photocatalysis
nickel-catalyzed

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