Discovery of *Trypanosoma brucei* inhibitors enabled by a | ResearchBunny

Index

Abstract

This research paper describes the development of a unified synthesis of diverse sulfonyl fluorides using photoredox-catalyzed dehydrogenative couplings. A library of 32 probes was created and screened against *Trypanosoma brucei*, identifying four with sub-micromolar anti-trypanosomal activity. Chemical proteomics revealed that the anti-trypanosomal activity likely arises from covalent modification of multiple protein targets.

Publisher

Communications Chemistry

Published On

Oct 19, 2024

Authors

Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright

Related Publications

Explore these studies to deepen your understanding of the subject.

Physics

A portrait of the Higgs boson by the CMS experiment ten years after the discovery

T. C. Collaboration

Physics

A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery

T. A. Collaboration

Chemistry

AlphaFlow: autonomous discovery and optimization of multi-step chemistry using a self-driven fluidic lab guided by reinforcement learning

A. A. Volk, R. W. Epps, et al.

Chemistry

Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry

C. Zhu, H. Yue, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny