Nickel catalyzed multicomponent stereodivergent synthesis of | ResearchBunny

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Abstract

This paper reports a three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes, yielding a wide range of trisubstituted alkenes with excellent chemo- and stereoselectivity. Electrochemistry with nickel produces the *E* isomer exclusively, while photocatalysis with nickel yields the *Z* isomer. A photo-assisted electrochemically enabled nickel-catalyzed protocol selectively delivers *Z*-trisubstituted alkenes without added photocatalysts.

Publisher

Nature Communications

Published On

Jun 10, 2022

Authors

Chen Zhu, Huifeng Yue, Magnus Rueping

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