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Neuroprotective role for RORA in Parkinson’s disease revealed by analysis of post-mortem brain and a dopaminergic cell line

Medicine and Health

Neuroprotective role for RORA in Parkinson’s disease revealed by analysis of post-mortem brain and a dopaminergic cell line

F. S. Al-zaid, M. J. Hurley, et al.

This intriguing study conducted by Felwah S. Al-Zaid, Michael J. Hurley, David T. Dexter, and Glenda E. Gillies reveals a sex-specific expression of RORA in Parkinson's disease, highlighting a potential therapeutic target. Discover how higher levels of RORA in females could lead to groundbreaking neuroprotective strategies against PD.

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Playback language: English
Abstract
This study investigates the sex-specific expression of RORA (retinoic acid receptor-related orphan receptor alpha) in Parkinson's disease (PD). Higher RORA levels were found in female control brains compared to males. In PD patients, male subjects showed significantly increased SNpc RORA expression compared to females. In vitro studies using a RORA agonist demonstrated neuroprotection in a PD cell culture model, affecting intracellular redox pathways crucial for neuronal survival. The findings suggest a sex-specific role for RORA in PD and highlight its translational potential as a therapeutic target.
Publisher
npj Parkinson's Disease
Published On
Jul 21, 2023
Authors
Felwah S. Al-Zaid, Michael J. Hurley, David T. Dexter, Glenda E. Gillies
Tags
RORA
Parkinson's disease
sex-specific expression
neuroprotection
cell culture model
therapeutic target
intracellular redox pathways

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