Medicine and Health

Nanoconstructs for theranostic application in cancer: Challenges and strategies to enhance the delivery

S. Mishra, T. Bhatt, et al.

Delve into the promising world of nanoconstructs for targeted cancer therapy! This innovative review by Shivani Mishra, Tanvi Bhatt, Hitesh Kumar, Rupshee Jain, Satish Shilpi, and Vikas Jain uncovers the potential of nanoparticles and ligands in enhancing drug delivery efficacy, while also addressing the challenges of biocompatibility and distribution.

00:00

~3 min • Beginner • English

Index

Abstract

Nanoconstructs are made up of nanoparticles and ligands and can deliver therapeutic and diagnostic payloads to desired sites. Various nanoparticulate platforms are used to create nanoconstructs for theranostic purposes to overcome cancer therapy limitations such as toxicity, nonspecific distribution, and uncontrolled release. Design strategies improve efficiency and specificity of loaded agents. Rather than active vs passive targeting, delivery is framed as autonomous vs nonautonomous systems considering blood flow and tumor microenvironment (TME). Computational modeling and AI/ML are being explored to address challenges. This review overviews attributes, challenges, and applications of nanoconstructs as theranostic agents in cancer.

Publisher

Frontiers in Pharmacology

Published On

Oct 26, 2023

Authors

Shivani Mishra, Tanvi Bhatt, Hitesh Kumar, Rupshee Jain, Satish Shilpi, Vikas Jain

DOI

https://doi.org/10.3389/fphar.2023.1101320

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