Medicine and Health

Myosteatosis and sarcopenia are linked to autonomous cortisol secretion in patients with aldosterone-producing adenomas

B. Lee, Y. Chang, et al.

This research explores the impact of autonomous cortisol secretion on muscle health in patients with adrenal aldosterone-producing adenomas. Conducted by a team of experts including Bo-Ching Lee and colleagues, the study reveals significant changes in intermuscular adipose tissue and skeletal muscle area following adrenalectomy, highlighting the links between ACS, myosteatosis, and sarcopenia.

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Abstract

Patients with adrenal aldosterone-producing adenomas (APA) face elevated cardiovascular risks, especially with co-secreted cortisol. This study investigated the association between autonomous cortisol secretion (ACS) in APA and muscle health. Data from 228 APA patients (76 with ACS) undergoing adrenalectomy were analyzed. ACS patients showed significantly higher intermuscular adipose tissue (IMAT) area, lower skeletal muscle area (SMA), and density (SMD). Multivariable regression confirmed ACS's association with IMAT and inverse association with SMA and SMD. Post-adrenalectomy, ACS patients showed decreased IMAT and increased SMA, while non-ACS patients showed increased visceral and subcutaneous adipose tissue. Myosteatosis and sarcopenia are linked to ACS in APA, improving after adrenalectomy.

Publisher

Hypertension Research

Published On

Oct 14, 2024

Authors

Bo-Ching Lee, Yu-Ling Chang, Po-Ting Chen, Li-Wen Liu, Kao-Lang Liu, Chin-Chen Chang, Vin-Cent Wu, Yen-Hung Lin

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