Medicine and Health

Multiplex real-time PCR in non-invasive respiratory samples to reduce antibiotic use in community-acquired pneumonia: a randomised trial

G. Abelend-alonso, L. Calatayud, et al.

This study by authors including Gabriela Abelend-Alonso and Laura Calatayud evaluates the use of multiplex real-time PCR compared to conventional testing in managing antibiotic use for community-acquired pneumonia. Despite the promising potential, the findings reveal no significant impact on reducing antibiotic therapy duration, underscoring the need for cautious implementation.

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Abstract

This randomized controlled trial assessed the safety and effectiveness of multiplex real-time PCR plus conventional microbiological testing compared to conventional testing alone in reducing antibiotic use for community-acquired pneumonia (CAP). 242 hospitalized adults with CAP were randomized. The primary endpoint (days of antibiotic therapy) showed no significant difference between groups (p=0.093). No differences were found in adverse events or 30-day mortality. The study concludes that routine implementation of multiplex real-time PCR for initial CAP testing isn't supported.

Publisher

Nature Communications

Published On

Aug 17, 2024

Authors

Gabriela Abelend-Alonso, Laura Calatayud, Alexander Rombauts, Yolanda Meije, Isabel Oriol, Nieves Sopena, Ariadna Padullés, Jordi Niubó, Alejandra Duarte, Jaume Llabrés, Judit Aranda, Carlota Guidol, Pau Satorra, Cristian Tebé, Carmen Ardanuy, Jordi Carratalà

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