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Multi-responsive chitosan-based hydrogels for controlled release of vincristine

Chemistry

Multi-responsive chitosan-based hydrogels for controlled release of vincristine

B. F. Far, M. Omrani, et al.

Discover innovative bio-hydrogels of chitosan-graft-glycerol and carboxymethyl chitosan-graft-glycerol developed for sustained vincristine sulfate release. This groundbreaking research conducted by Bahareh Farasati Far, Mohsen Omrani, Mohammad Reza Naimi Jamal, and Shahrzad Javanshir demonstrates high swelling ratios and encapsulation efficiency, paving the way for effective breast cancer drug delivery.

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Playback language: English
Abstract
This work aims to develop multi-reactive, safe, and highly swellable bio-hydrogels of chitosan-graft-glycerol (CS-g-gly) and carboxymethyl chitosan-graft-glycerol (CMCS-g-gly) for sustained and controlled vincristine sulfate release. Hydrogels showed high swelling ratios under various conditions. Vincristine encapsulation efficiency was high (72.28-89.97% for VCR/CS-g-gly and 56.97-71.91% for VCR/CMCS-g-gly). VCR/CS-g-gly exhibited sustained release, reaching 82% release after 120 hours. In vitro studies showed no significant cytotoxicity in MCF-7 and MCF-10 cells, indicating potential for effective drug delivery to breast cancer cells.
Publisher
Communications Chemistry
Published On
Feb 10, 2023
Authors
Bahareh Farasati Far, Mohsen Omrani, Mohammad Reza Naimi Jamal, Shahrzad Javanshir
Tags
bio-hydrogels
chitosan
vincristine sulfate
drug delivery
sustained release
cytotoxicity
breast cancer

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