Chemistry

A visible light-activated azo-fluorescent switch for imaging-guided and light-controlled release of antimycotics

Y. Huang, X. Zeng, et al.

Explore groundbreaking research conducted by Yurou Huang, Xiaoyan Zeng, Xiaoxie Ma, Zibo Lin, Jiayue Sun, Wang Xiao, Sheng Hua Liu, Jun Yin, and Guang-Fu Yang on a visible light-responsive azo-fluorescent switch. This innovative switch enhances fluorescence imaging and facilitates a light-responsive platform for controlled antimycotic release, effectively combating *Rhizoctonia solani* while extending efficacy compared to traditional small-molecule treatments.

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Abstract

This paper introduces a visible light-responsive azo-fluorescent switch that can be monitored via fluorescence imaging. Visible light irradiation triggers isomerization, altering fluorescence and enabling imaging-based tracking. The study demonstrates that liposome-encapsulated nanoparticles containing this azo switch exhibit nanocavity size changes during isomerization, facilitating the creation of a light-responsive nanoplatform for controlled antimycotic release. Natural light activation of these nanoparticles carrying an antimycotic agent effectively kills *Rhizoctonia solani*, extending the holding period compared to small-molecule antimycotics. This strategy offers a potentially widely applicable approach for controlled drug delivery.

Publisher

Nature Communications

Published On

Oct 07, 2024

Authors

Yurou Huang, Xiaoyan Zeng, Xiaoxie Ma, Zibo Lin, Jiayue Sun, Wang Xiao, Sheng Hua Liu, Jun Yin, Guang-Fu Yang

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