logo
ResearchBunny Logo
An aptamer-based depot system for sustained release of small molecule therapeutics

Medicine and Health

An aptamer-based depot system for sustained release of small molecule therapeutics

D. Wang, Y. Li, et al.

Explore how DNA aptamers can revolutionize the delivery of hydrophilic small molecule therapeutics! Dali Wang, Yang Li, Xiaoran Deng, and their team have created a sustained-release drug depot system that minimizes systemic toxicity and enhances local anesthetic effects. This innovative approach holds promising potential for effective postoperative pain management.

00:00
00:00
Playback language: English
Abstract
Delivery of hydrophilic small molecule therapeutics is challenging. This study uses the specific interaction between DNA aptamers and drugs to create sustained-release drug depot systems. Phosphorothioate-modified aptamers formed non-covalent complexes with site 1 sodium channel blockers tetrodotoxin and saxitoxin, prolonging local anesthesia and reducing systemic toxicity. The effects were specific to the targeted compounds. This establishes aptamers as highly specific, modifiable drug delivery systems with potential for managing postoperative pain.
Publisher
Nature Communications
Published On
Apr 28, 2023
Authors
Dali Wang, Yang Li, Xiaoran Deng, Matthew Torre, Zipei Zhang, Xiyu Li, Wei Zhang, Kathleen Cullion, Daniel S. Kohane, Christopher B. Weldon
Tags
DNA aptamers
drug delivery
sustained release
local anesthesia
systemic toxicity
postoperative pain
small molecule therapeutics

Related Publications

Explore these studies to deepen your understanding of the subject.

Impact of an evidence-based training for educators on bystander intervention for the prevention of violence against LGBTI+ youth
Education

Impact of an evidence-based training for educators on bystander intervention for the prevention of violence against LGBTI+ youth

O. Rios-gonzalez, J. C. Peña-axt, et al.

Towards an intelligent blended system of learning activities model for New Zealand institutions: an investigative approach
Education

Towards an intelligent blended system of learning activities model for New Zealand institutions: an investigative approach

A. Adel and J. Dayan

Not-for-profit or for-profit? Research on the high-quality development path of private universities in China based on system dynamics
Education

Not-for-profit or for-profit? Research on the high-quality development path of private universities in China based on system dynamics

S. Duan, H. Yang, et al.

Motivations for user satisfaction of mobile fitness applications: An analysis of user experience based on online review comments
Health and Fitness

Motivations for user satisfaction of mobile fitness applications: An analysis of user experience based on online review comments

H. Ahn and E. Park

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny