Medicine and Health

Mucosa-Associated Microbiota and Metabolome in Colorectal Polyps: A Novel Sampling Strategy Reveals Tumor Stage-Specific Signatures

M. Clavenna, M. L. Vecchia, et al.

This groundbreaking study by M.G. Clavenna and colleagues uncovers the intricate relationship between gut microbiota and metabolome composition in relation to colorectal cancer (CRC). With a novel sampling technique, they reveal striking microbial and metabolic differences between polyps of varying dysplasia grades, providing compelling insights into CRC initiation and progression.

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Abstract

This study investigated the association between gut microbiota and metabolome composition and colorectal cancer (CRC) development. A novel sampling technique was used to collect mucosa-associated microbiota (MAM) and metabolome from the surface of colon polyps without compromising tissue integrity. The results showed distinct microbial and metabolic signatures in low-grade versus high-grade dysplastic polyps, suggesting a role for specific bacteria and metabolites in CRC initiation and progression. Driver bacteria were enriched in low-grade polyps, while passenger bacteria were enriched in high-grade polyps. Integrated analysis revealed correlations between specific bacterial genera and metabolite classes.

Publisher

Cancers

Published On

Dec 15, 2023

Authors

M.G. Clavenna, M. La Vecchia, M. Sculco, S. Joseph, E. Barberis, E. Amede, M. Mellai, S. Brossa, G. Borgonovi, P. Occhipinti, R. Boldorini, E. Robotti, A. Aspesi, I. Degano, A. Aimaretti

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