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Abstract
Maternal high-fat diet (moHF) alters offspring's metabolic profile in a sex-dependent manner. Female offspring exhibit remodeled triglyceride profiles in SAT and BAT, increased thermogenesis, and enhanced brown adipocyte differentiation in BAT, potentially mitigating metabolic complications later in life. Male offspring, however, show BAT whitening, VAT hyperplasia, and impaired metabolic profiles. moHF differentially programs gene expression in WAT and BAT of both sexes.
Publisher
International Journal of Obesity
Published On
Jan 07, 2022
Authors
Christina Savva, Luisa A. Helguero, Marcela González-Granillo, Tânia Melo, Daniela Couto, Byambajav Buyandelger, Sonja Gustafsson, Jianping Liu, Maria Rosário Domingues, Xidan Li, Marion Korach-André
Tags
maternal high-fat diet
metabolic profile
sex-dependent
triglyceride profiles
thermogenesis
gene expression
brown adipocyte differentiation

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