Medicine and Health

Longitudinal associations of dietary fiber and its source with 48-week weight loss maintenance, cardiometabolic risk factors and glycemic status under metformin or acarbose treatment: a secondary analysis of the March randomized trial

J. Liu, Y. An, et al.

This research conducted by Jia Liu, Yu An, Ning Yang, Yuan Xu, and Guang Wang delves into the critical relationship between dietary fiber intake and clinical outcomes in newly diagnosed type 2 diabetes mellitus patients. Discover how different fiber sources can significantly impact glycemic control and overall treatment efficacy.

00:00

Playback language: English

Index

Abstract

This secondary analysis of the MARCH trial examined the longitudinal associations between dietary fiber intake and clinical outcomes in 551 newly diagnosed type 2 diabetes mellitus (T2DM) patients treated with metformin or acarbose for 48 weeks. Higher total and whole grain fiber intake correlated with improved β-cell function and glycemic control under acarbose. Legume fiber intake was linked to better glycemic control in both treatment groups and weight loss under metformin. A high-carbohydrate, low-fiber diet showed mixed effects, negatively impacting glycemic control and HDL-C under acarbose but positively influencing insulin sensitivity and weight loss under metformin. The study highlights the importance of considering dietary fiber sources and their interaction with oral glucose-lowering medications for optimal T2DM management.

Publisher

Nutrition and Diabetes

Published On

Oct 02, 2024

Authors

Jia Liu, Yu An, Ning Yang, Yuan Xu, Guang Wang

Related Publications

Explore these studies to deepen your understanding of the subject.

Health and Fitness

Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment

S. B. K. Jensen, C. Janus, et al.

Medicine and Health

Mediterranean diet as a strategy for preserving kidney function in patients with coronary heart disease with type 2 diabetes and obesity: a secondary analysis of CORDIOPREV randomized controlled trial

A. Podadera-herreros, A. P. A. Larriva, et al.

Medicine and Health

The effects of omega 3 fatty acids on the serum concentrations of pro inflammatory cytokines and depression status in patients with bipolar disorder: A randomized double-blind controlled clinical trial

H. Eslahi, M. Shakiba, et al.

Medicine and Health

Determinants of weight, psychological status, food contemplation and lifestyle changes in patients with obesity during the COVID-19 lockdown: a nationwide survey using multiple correspondence analysis

A. Caretto, S. Pintus, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny