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Abstract
Weight regain after weight loss is a major challenge. This randomized controlled trial investigated the effects of exercise, liraglutide, or both on eating and sedentary behavior after diet-induced weight loss. The placebo group showed decreased postprandial appetite suppression and increased sedentary time, with weight regain. Liraglutide prevented appetite decrease and maintained weight loss. Exercise did not increase appetite or sedentary behavior despite weight loss maintenance. The combination treatment increased cognitive restraint and decreased sedentary time, facilitating additional weight loss. Targeting both eating and sedentary behavior may be crucial for preventing weight regain.
Publisher
Nature Communications
Published On
Aug 15, 2022
Authors
Simon Birk Kjær Jensen, Charlotte Janus, Julie Rehné Lundgren, Christian Rimer Juhl, Rasmus Michael Sandsdal, Lisa Møller Olsen, Anne Andresen, Signe Amalie Borg, Ida Christine Jacobsen, Graham Finlayson, Bente Merete Stallknecht, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov
Tags
weight regain
liraglutide
exercise
sedentary behavior
diet-induced weight loss
appetite suppression
cognitive restraint

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