Medicine and Health

Lactobacillus fermentum LM1016 Ameliorates Diet-Induced Obesity by Modulating Bile Acid Signaling and Adipose Tissue Inflammation

Y. Y, K. G, et al.

Discover how Lactobacillus fermentum LM1016 could be the game-changer in combating diet-induced obesity in mice. Researchers Yoon Y, Kim G, Park J-h, Nam M, Jeong M, Fong S, and Park H demonstrated its ability to reduce body weight, improve glucose tolerance, and lower key metabolic markers. This study unveils intriguing mechanisms that could pave the way for innovative weight management strategies.

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Abstract

This study investigated the protective effects of Lactobacillus fermentum LM1016 against diet-induced obesity in mice. Results showed that LM1016 significantly reduced body weight gain, improved glucose tolerance, and lowered serum insulin, leptin, and cholesterol levels. The mechanism involved increased bile acid signaling, enhanced brown adipose tissue function, and reduced adipose tissue inflammation. Metabolomic analysis revealed that LM1016 produced metabolites, including linoleic acid, which inhibited adipogenesis and inflammation in vitro.

Publisher

Experimental & Molecular Medicine

Published On

Sep 11, 2020

Authors

Yoon Y, Kim G, Park J-h, Nam M, Jeong M, Fong S, Park H

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