This study investigated the protective effects of Lactobacillus fermentum LM1016 against diet-induced obesity in mice. Results showed that LM1016 significantly reduced body weight gain, improved glucose tolerance, and lowered serum insulin, leptin, and cholesterol levels. The mechanism involved increased bile acid signaling, enhanced brown adipose tissue function, and reduced adipose tissue inflammation. Metabolomic analysis revealed that LM1016 produced metabolites, including linoleic acid, which inhibited adipogenesis and inflammation in vitro.
Publisher
Experimental & Molecular Medicine
Published On
Sep 11, 2020
Authors
Yoon Y, Kim G, Park J-h, Nam M, Jeong M, Fong S, Park H
Tags
Lactobacillus fermentum
diet-induced obesity
mice study
metabolomic analysis
inflammation
glucose tolerance
body weight
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