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Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration

Engineering and Technology

Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration

S. Camarero-espinosa and L. Moroni

Discover groundbreaking research by Sandra Camarero-Espinosa and Lorenzo Moroni on dynamic, additive-manufactured Janus scaffolds that utilize ultrasound to stimulate bone regeneration. These innovative scaffolds not only foster cell proliferation but also enhance osteogenic differentiation, making significant strides in tissue engineering.

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Playback language: English
Abstract
This paper reports the fabrication and use of dynamic, additive-manufactured Janus scaffolds activated by external ultrasound, creating nanovibrations that stimulate bone regeneration. These scaffolds, formed through phase separation of PCL and PLA blends, act as ultrasound transducers. Remote stimulation enhanced cell proliferation, matrix deposition, and osteogenic differentiation of hBMSCs via voltage-gated calcium ion channels.
Publisher
Nature Communications
Published On
Mar 17, 2021
Authors
Sandra Camarero-Espinosa, Lorenzo Moroni
Tags
Janus scaffolds
bone regeneration
ultrasound stimulation
hBMSCs
PCL-PLA blends
osteogenic differentiation
cell proliferation

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