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Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration

Medicine and Health

Strontium-incorporated bioceramic scaffolds for enhanced osteoporosis bone regeneration

Q. Wu, L. Hu, et al.

Discover how the innovative incorporation of strontium into bioactive scaffolds can significantly enhance bone regeneration in osteoporosis. This groundbreaking research by Qianju Wu, Longwei Hu, Ran Yan, Junfeng Shi, Hao Gu, Yuwei Deng, Ruixue Jiang, Jin Wen, and Xinquan Jiang reveals impressive improvements in biocompatibility, osteogenesis, and angiogenesis, highlighting the potential of trace elements in advancing bone health.

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Playback language: English
Abstract
This study fabricated bioactive scaffolds by incorporating strontium (Sr) into amino-functional mesoporous bioactive glass (MBG) to enhance bone regeneration in osteoporosis. In vitro and in vivo studies in an osteoporotic rat model demonstrated improved biocompatibility, osteogenesis, and angiogenesis with Sr incorporation. Bioinformatics analysis revealed that Sr-incorporated scaffolds reduced reactive oxygen species by activating the cAMP/PKA pathway, thus promoting osteogenesis and exhibiting an anti-osteoporosis effect. The findings highlight the potential of incorporating trace elements into scaffolds for bone regeneration in osteoporosis.
Publisher
Bone Research
Published On
Aug 23, 2022
Authors
Qianju Wu, Longwei Hu, Ran Yan, Junfeng Shi, Hao Gu, Yuwei Deng, Ruixue Jiang, Jin Wen, Xinquan Jiang
Tags
bioactive scaffolds
strontium
osteoporosis
bone regeneration
angiogenesis
osteogenesis
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