Janus 3D printed dynamic scaffolds for nanovibration-driven bone | ResearchBunny

Index

Abstract

This paper reports the fabrication and use of dynamic, additive-manufactured Janus scaffolds activated by external ultrasound, creating nanovibrations that stimulate bone regeneration. These scaffolds, formed through phase separation of PCL and PLA blends, act as ultrasound transducers. Remote stimulation enhanced cell proliferation, matrix deposition, and osteogenic differentiation of hBMSCs via voltage-gated calcium ion channels.

Publisher

Nature Communications

Published On

Mar 17, 2021

Authors

Sandra Camarero-Espinosa, Lorenzo Moroni

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