This study investigated the impact of varying dietary zinc levels on glucose-stimulated zinc secretion (GSZS) in healthy and malignant mouse prostates using MRI and synchrotron radiation X-ray fluorescence (SR-XRF). Zinc deficiency caused systemic dysregulation and weight loss. Healthy mice showed increased zinc efflux from the prostate with higher dietary zinc, unlike TRAMP mice (prostate cancer model). This suggests that dietary zinc supplementation before GSZS MRI may enhance image contrast, improving prostate cancer detection.
Publisher
npj Imaging
Published On
Nov 06, 2024
Authors
Veronica Clavijo Jordan, André F. Martins, Erica Dao, Kalotina Geraki, Sara Chirayil, Xiaodong Wen, Pooyan Khalighinejad, Daniel Parrott, Xiaojing Wang, Patricia Gonzalez Pagan, Neil Rofsky, Michael Farquharson, A. Dean Sherry
Tags
zinc secretion
MRI
prostate cancer
dietary zinc
GLUT metabolism
image contrast
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