Medicine and Health

Impact of dietary zinc on stimulated zinc secretion MRI in the healthy and malignant mouse prostate

V. C. Jordan, A. F. Martins, et al.

This study reveals how dietary zinc levels influence glucose-stimulated zinc secretion in mouse prostates, potentially enhancing MRI image contrast for better prostate cancer detection. Conducted by a team of experts including Veronica Clavijo Jordan and André F. Martins, the findings suggest a promising avenue for improving diagnostic imaging in prostate cancer.

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Abstract

This study investigated the impact of varying dietary zinc levels on glucose-stimulated zinc secretion (GSZS) in healthy and malignant mouse prostates using MRI and synchrotron radiation X-ray fluorescence (SR-XRF). Zinc deficiency caused systemic dysregulation and weight loss. Healthy mice showed increased zinc efflux from the prostate with higher dietary zinc, unlike TRAMP mice (prostate cancer model). This suggests that dietary zinc supplementation before GSZS MRI may enhance image contrast, improving prostate cancer detection.

Publisher

npj Imaging

Published On

Nov 06, 2024

Authors

Veronica Clavijo Jordan, André F. Martins, Erica Dao, Kalotina Geraki, Sara Chirayil, Xiaodong Wen, Pooyan Khalighinejad, Daniel Parrott, Xiaojing Wang, Patricia Gonzalez Pagan, Neil Rofsky, Michael Farquharson, A. Dean Sherry

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