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Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study

Medicine and Health

Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study

D. Junker, M. Wu, et al.

This groundbreaking study explores how an 8-week low-calorie diet has the potential to significantly impact adipose tissue in adults with obesity. The authors observed notable weight loss and reductions in fat deposits, providing insights into the dynamics of subcutaneous and visceral fat loss, particularly in the lower abdominopelvic area.

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Playback language: English
Abstract
This study assessed the impact of an 8-week low-calorie diet (LCD) on adipose tissue (AT) depots in adults with obesity using MRI. Significant weight loss and reductions in all MRI-based AT parameters were observed. Absolute SAT loss exceeded VAT loss, while relative apparent lipid loss was higher in VAT. The lower abdominopelvic third showed the most significant reduction. Normalized baseline SAT volume in the lower abdominopelvic third was the strongest predictor of AT and apparent lipid loss, with smaller volumes associated with greater loss.
Publisher
International Journal of Obesity
Published On
Jun 26, 2024
Authors
Daniela Junker, Mingming Wu, Anna Reik, Johannes Raspe, Selina Rupp, Jessie Han, Stella M. Näbauer, Meike Wiechert, Arun Somasundaram, Egon Burian, Birgit Waschulzik, Marcus R. Makowski, Hans Hauner, Christina Holzapfel, Dimitrios C. Karampinos
Tags
obesity
low-calorie diet
adipose tissue
MRI
weight loss
subcutaneous fat
visceral fat

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