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Abstract
This study evaluates neutralizing antibody responses and efficacy against BA.5 challenge in male Syrian hamsters after primary vaccination with Ad26.COV2.S (Janssen) or BNT162b2 (Pfizer/BioNTech) followed by homologous or heterologous boosters. One high or low dose of Ad26.COV2.S provided more durable immunity than two doses of BNT162b2, and the NVX-CoV2373 booster provided the strongest immunity and protection against BA.5 infection. The data demonstrate the immunogenicity and efficacy of different prime/boost regimens against BA.5.
Publisher
Nature Communications
Published On
Jul 17, 2023
Authors
Rafael R. G. Machado, Jordyn L. Walker, Dionna Scharton, Grace H. Rafael, Brooke M. Mitchell, Rachel A. Reyna, William M. de Souza, Jianying Liu, David H. Walker, Jessica A. Plante, Kenneth S. Plante, Scott C. Weaver
Tags
neutralizing antibodies
BA.5 challenge
Ad26.COV2.S
BNT162b2
vaccination
immunity
booster

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