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Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

Medicine and Health

Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

S. Sharma, T. Vercruysse, et al.

Discover how a new yellow fever 17D vaccine is tackling COVID-19 variants! This groundbreaking study, conducted by an expert team from KU Leuven, reveals enhanced protection against emerging strains like Beta, Gamma, and Omicron. With vaccinated hamsters showing strong resistance and no Delta transmission, the findings underscore the importance of updated vaccines in the fight against COVID-19.

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Playback language: English
Abstract
Current COVID-19 vaccines, based on ancestral SARS-CoV-2 strains, are challenged by emerging variants. This study demonstrates that a yellow fever 17D (YF17D) vectored vaccine with a prototypic spike protein effectively protects against ancestral and Alpha variants but not Beta. However, an updated YF17D vaccine with an evolved antigen significantly improved neutralizing antibody responses against Beta, Gamma, and Omicron variants, while maintaining immunogenicity against ancestral and Delta variants. Vaccinated hamsters resisted challenge by all VOCs, showed undetectable virus levels, and improved lung pathology. Importantly, vaccinated hamsters did not transmit the Delta variant. This highlights the need for updated vaccines to maintain efficacy against emerging variants.
Publisher
Nature Communications
Published On
Nov 04, 2022
Authors
Sapna Sharma, Thomas Vercruysse, Lorena Sanchez-Felipe, Winnie Kerstens, Madina Rasulova, Lindsey Bervoets, Carolien De Keyzer, Rana Abdelnabi, Caroline S. Foo, Viktor Lemmens, Dominique Van Looveren, Piet Maes, Guy Baele, Birgit Weynand, Philippe Lemey, Johan Neyts, Hendrik Jan Thibaut, Kai Dallmeier
Tags
COVID-19
vaccines
yellow fever
SARS-CoV-2 variants
neutralizing antibodies
hamster model
vaccine efficacy
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