Medicine and Health

An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters

S. Deng, Y. Liu, et al.

This groundbreaking study by Shaofeng Deng and colleagues introduces an intranasal vaccine, DelNS1-RBD4N-DAF, that not only induced strong immune responses in animal models but also effectively prevented SARS-CoV-2 replication in respiratory tissues, outperforming traditional intramuscular vaccines. This promising LAIV could change the game in controlling COVID-19 transmission.

00:00

Playback language: English

Index

Abstract

Current COVID-19 vaccines effectively reduce severe disease and death but less optimally prevent infection. This study developed an intranasal vaccine (DelNS1-RBD4N-DAF) using a live-attenuated influenza virus expressing the SARS-CoV-2 receptor-binding domain (RBD). In mice and hamsters, DelNS1-RBD4N-DAF induced high neutralizing antibody levels and robust T cell responses. Crucially, intranasal DelNS1-RBD4N-DAF, unlike intramuscular mRNA vaccine (BNT162b2), prevented SARS-CoV-2 replication (including Delta and Omicron BA.2 variants) in respiratory tissues. This LAIV warrants further human evaluation for SARS-CoV-2 transmission control and as a dual-function influenza/COVID-19 vaccine.

Publisher

Nature Communications

Published On

Apr 12, 2023

Authors

Shaofeng Deng, Ying Liu, Rachel Chun-Yee Tam, Pin Chen, Anna Jinxia Zhang, Bobo Wing-Yee Mok, Teng Long, Anja Kukic, Runhong Zhou, Haoran Xu, Wenjun Song, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Zhiwei Chen, Kwok-Yung Yuen, Pui Wang, Honglin Chen

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

S. Hattori, N. Higashi-kuwata, et al.

Medicine and Health

Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

S. Sharma, T. Vercruysse, et al.

Medicine and Health

Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters

R. R. G. Machado, J. L. Walker, et al.

Medicine and Health

Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG)

A. J. M. Aabakke, T. G. Petersen, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny