Medicine and Health

Identification of a highly stable bioactive 3-hydroxyproline-containing tripeptide in human blood after collagen hydrolysate ingestion

Y. Taga, Y. Iwasaki, et al.

This groundbreaking study reveals the presence of the Gly-3Hyp-4Hyp tripeptide in human blood after consuming porcine skin collagen hydrolysate. Its notable resistance to peptidase allows it to remain effective for hours. Conducted by Yuki Taga, Yu Iwasaki, Chisa Tometsuka, Noriko Funato, Yasutaka Shigemura, and Masashi Kusubata, this research highlights its potential health benefits, including promoting skin and bone health.

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Abstract

This study identified Gly-3Hyp-4Hyp tripeptide in human blood at high concentrations after ingesting porcine skin collagen hydrolysate. Its high resistance to peptidase/protease, demonstrated by incubation with mouse plasma, allowed it to maintain maximum concentration for 4 hours post-ingestion. In mice, bovine tendon collagen hydrolysate (higher 3Hyp content) further increased blood Gly-3Hyp-4Hyp levels. Gly-3Hyp-4Hyp also showed chemotactic activity on skin fibroblasts and promoted osteoblast differentiation, highlighting its potential for health benefits.

Publisher

npj Science of Food

Published On

Jun 03, 2022

Authors

Yuki Taga, Yu Iwasaki, Chisa Tometsuka, Noriko Funato, Yasutaka Shigemura, Masashi Kusubata

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