Absence of a sexual dimorphism in postprandial glucose metabolism after administration of a balanced mixed meal in healthy young volunteers

This study investigated sex differences in glucose metabolism after a balanced mixed meal normalized to individual daily energy expenditure in 36 healthy young volunteers (18 men, 18 women). Fasting glucose was lower in women, but fasting insulin and C-peptide were similar. Linear mixed models showed no significant sex effect or sex-time interaction on postprandial glucose, insulin, or C-peptide. Area under the curve analysis revealed similar glycemic, insulinemic, and C-peptide responses between sexes. The study concludes that there is no sexual dimorphism in carbohydrate metabolism regulation in young adults when consuming a meal normalized to individual energy expenditure.

Alessandro Leone, Ramona De Amicis, Simona Bertoli, Angela Spadafranca, Giulia De Carlo, Alberto Battezzati