logo
ResearchBunny Logo
Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation

Medicine and Health

Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation

X. Xu, T. Xie, et al.

This groundbreaking research by Xiaoyan Xu and colleagues reveals how Hsc70 can significantly enhance the efficacy of immune checkpoint therapies by promoting the degradation of PD-L1. By inhibiting the CMTM6-PD-L1 interaction, Hsc70 plays a crucial role in reducing tumor growth and improving anti-tumor immunity, particularly when paired with the Hsp90α/β inhibitor AUY-922.

00:00
00:00
Playback language: English
Citation Metrics
Citations
0
Influential Citations
0
Reference Count
0

Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

Related Publications

Explore these studies to deepen your understanding of the subject.

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
Medicine and Health

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

X. Zhang, X. Huang, et al.

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Medicine and Health

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

J. Yi, O. Tavana, et al.

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation
Medicine and Health

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation

J. Cheng, G. Zhang, et al.

Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy
Medicine and Health

Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy

Y. Li, Y. Cong, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny