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How autoreactive thymocytes differentiate into regulatory versus effector CD4<sup>+</sup> T cells after avoiding clonal deletion

Medicine and Health

How autoreactive thymocytes differentiate into regulatory versus effector CD4<sup>+</sup> T cells after avoiding clonal deletion

X. Tai, A. Indart, et al.

This groundbreaking study explores the differentiation of autoreactive thymocytes into regulatory and effector CD4+ T cells upon escaping clonal deletion. The research reveals that TGF-β plays a pivotal role in promoting Treg differentiation by disrupting weak agonist signals, while persistent signaling favors Teff cell formation. Conducted by a dedicated team of researchers, this study opens new avenues for understanding thymic selection in immunity.

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